Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
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چکیده
منابع مشابه
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production
Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3), the center of the classic antigen-binding site. To assess the role of D(H) RF1-encoded tyrosine and glycine in regulating CDR-H3 content and potentially influencing B cell function, we created mice limited to a single D(H) encoding asparagine, histidine, and arginines in RF1. ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2006
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20052217